Perioperative cognitive protection

被引：56

作者：

Brown, C. ^{[1
]}

Deiner, S. ^{[2
,3
,4
]}

机构：

[1] Johns Hopkins Univ, Dept Anesthesiol & Crit Care Med, Sch Med, Sheikh Zayed Tower,1800 Orleans St, Baltimore, MD 21287 USA

[2] Icahn Sch Med Mt Sinai, Dept Anesthesiol, 1 Gustave L Levy Pl,Box 1010, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Neurosurg, 1 Gustave L Levy Pl,Box 1010, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Geriatr & Palliat Care, 1 Gustave L Levy Pl,Box 1010, New York, NY 10029 USA

来源：

BRITISH JOURNAL OF ANAESTHESIA | 2016年 / 117卷

关键词：

cognition; delirium; perioperative period; surgery; CORONARY-ARTERY-BYPASS; COMPREHENSIVE GERIATRIC ASSESSMENT; ELDER LIFE PROGRAM; CEREBRAL AUTOREGULATION THRESHOLD; NEAR-INFRARED SPECTROSCOPY; PUMP CARDIAC-SURGERY; POSTOPERATIVE DELIRIUM; CARDIOPULMONARY BYPASS; OLDER-ADULTS; ALZHEIMERS-DISEASE;

D O I：

10.1093/bja/aew361

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

There is significant evidence that many older surgical patients experience at least a transient decrease in cognitive function. Although there is still equipoise regarding the degree, duration, and mechanism of cognitive dysfunction, there is a concurrent need to provide best-practice clinical evidence. The two major cognitive disorders seen after surgery are postoperative delirium and postoperative cognitive dysfunction. Delirium is a public health problem; millions of dollars are spent annually on delirium-related medical resource use and prolonged hospital stays. Postoperative cognitive dysfunction is a research construct that historically signifies decline in performance on a neuropsychiatric test or group of tests and begins days to weeks after surgery. This review focuses on the current state of information gathered by several interdisciplinary stake-holder groups. Although there is still a need for high-level evidence to guide clinical practice, there is an emerging literature that can guide practitioners.

引用

页码：52 / 61

页数：10

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