Postburn Hypermetabolism: Past, Present, and Future

被引：72

作者：

Jeschke, Marc G. ^{[1
,2
,3
]}

机构：

[1] Sunnybrook Hlth Sci Ctr, Ross Tilley Burn Ctr, 2075 Bayview Ave,Rm D704, Toronto, ON M4N 3M5, Canada

[2] Univ Toronto, Dept Surg, Div Plast Surg, Toronto, ON, Canada

[3] Univ Toronto, Dept Immunol, Toronto, ON, Canada

来源：

JOURNAL OF BURN CARE & RESEARCH | 2016年 / 37卷 / 02期

基金：

美国国家卫生研究院;

关键词：

TRACE-ELEMENT SUPPLEMENTATION; BURNED PEDIATRIC-PATIENTS; GROWTH-HORMONE TREATMENT; FREE FATTY-ACIDS; ENDOPLASMIC-RETICULUM STRESS; RESTING ENERGY-EXPENDITURE; INSULIN-TREATMENT IMPROVES; MUSCLE PROTEIN CATABOLISM; ACUTE-PHASE RESPONSE; GLUCOSE-METABOLISM;

D O I：

10.1097/BCR.0000000000000265

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Hypermetabolism is the ubiquitous response to a severe burn injury, which was first described in the nineteenth century. Despite identification of important components of this complex response, hypermetabolism is still not well understood in its entirety. This article describes this incredibly fascinating response and the understanding we have gained over the past 100 years. Additionally, this article describes novel insights and delineates treatment options to modulate postburn hypermetabolism with the goal to improve outcomes of burn patients.

引用

页码：86 / 96

页数：11

共 153 条

[31] THE EFFECT OF INSULIN ON THE DISPOSAL OF INTRAVENOUS GLUCOSE - RESULTS FROM INDIRECT CALORIMETRY AND HEPATIC AND FEMORAL VENOUS CATHETERIZATION
DEFRONZO, RA
JACOT, E
JEQUIER, E
MAEDER, E
WAHREN, J
FELBER, JP
[J]. DIABETES, 1981, 30 (12) : 1000 - 1007
[32] Growth hormone therapy in critically ill patients
Demling, R
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (11) : 837 - 839
[33] Oxandrolone induced lean mass gain during recovery from severe burns is maintained after discontinuation of the anabolic steroid
Demling, RH
DeSanti, L
[J]. BURNS, 2003, 29 (08) : 793 - 797
[34] Oxandrolone, an anabolic steroid, significantly increases the rate of weight gain in the recovery phase after major burns
Demling, RH
DeSanti, L
[J]. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1997, 43 (01) : 47 - 51
[35] The rate of restoration of body weight after burn injury, using the anabolic agent oxandrolone, is not age dependent
Demling, RH
DeSanti, L
[J]. BURNS, 2001, 27 (01) : 46 - 51
[36] Metabolic management of patients with severe burns
Demling, RH
Seigne, P
[J]. WORLD JOURNAL OF SURGERY, 2000, 24 (06) : 673 - 680
[37] DOLECEK R, 1989, Keio Journal of Medicine, V38, P262
[38] Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
Dresner, A
Laurent, D
Marcucci, M
Griffin, ME
Dufour, S
Cline, GW
Slezak, LA
Andersen, DK
Hundal, RS
Rothman, DL
Petersen, KF
Shulman, GI
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (02) : 253 - 259
[39] Hypoglycemia and Outcome in Critically Ill Patients
Egi, Moritoki
Bellomo, Rinaldo
Stachowski, Edward
French, Craig J.
Hart, Graeme K.
Taori, Gopal
Hegarty, Colin
Bailey, Michael
[J]. MAYO CLINIC PROCEEDINGS, 2010, 85 (03) : 217 - 224
[40] A submaximal dose of insulin promotes net skeletal muscle protein synthesis in patients with severe burns
Ferrando, AA
Chinkes, DL
Wolf, SE
Matin, S
Herndon, DN
Wolfe, RR
[J]. ANNALS OF SURGERY, 1999, 229 (01) : 11 - 18

← 1 2 3 4 5 6 7 8 9 10 →