BRCA1 ubiquitylation of CtIP: Just the tIP of the iceberg?

被引：14

作者：

Barber, Louise J. ^{[1
]}

Boulton, Simon J. ^{[1
]}

机构：

[1] London Res Inst, Clare Hall Labs, Canc Res UK, DNA Damage Response Lab, S Mimms EN6 3LD, Herts, England

来源：

DNA REPAIR | 2006年 / 5卷 / 12期

关键词：

CtIP; BRCA1; ubiquitylation; E3-ubiquitin ligase;

D O I：

10.1016/j.dnarep.2006.08.009

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ubiquitylation is an important regulatory mechanism of many cellular processes. The breast and ovarian cancer-specific tumour suppressor BRCA1 is well acknowledged to be a RING/E3 ubiquitin ligase, however, identification of its physiological substrates has proved elusive. Recently published data have shown that the BRCA1-interacting protein CtIP is in fact ubiquitylated by BRCA1, and opens new avenues for the isolation of other substrate proteins. (c) 2006 Elsevier B.V. All rights reserved.

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页码：1499 / 1504

页数：6

相关论文

共 54 条

[1] Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis [J].

Bienko, M ;

Green, CM ;

Crosetto, N ;

Rudolf, F ;

Zapart, G ;

Coull, B ;

Kannouche, P ;

Wider, G ;

Peter, M ;

Lehmann, AR ;

Hofmann, K ;

Dikic, I .

SCIENCE, 2005, 310 (5755) :1821-1824

[2] BRCA1-mediated ubiquitylation [J].

Boulton, Simon J. .

CELL CYCLE, 2006, 5 (14) :1481-1486

[3] BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans [J].

Boulton, SJ ;

Martin, JS ;

Polanowska, J ;

Hill, DE ;

Gartner, A ;

Vidal, M .

CURRENT BIOLOGY, 2004, 14 (01) :33-39

[4] Binding and recognition in the assembly of an active BRCA1 /BARD1 ubiquitin-ligase complex [J].

Brzovic, PS ;

Keeffe, JR ;

Nishikawa, H ;

Miyamoto, K ;

Fox, D ;

Fukuda, M ;

Ohta, T ;

Klevit, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (10) :5646-5651

[5] BRCA1 RING domain cancer-predisposing mutations - Structural consequences and effects on protein-protein interactions [J].

Brzovic, PS ;

Meza, JE ;

King, MC ;

Klevit, RE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (44) :41399-41406

[6] Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis haploid insufficiency [J].

Chen, PL ;

Liu, F ;

Cai, SN ;

Lin, XQ ;

Li, AH ;

Chen, YM ;

Gu, BN ;

Lee, EYHP ;

Lee, WH .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (09) :3535-3542

[7] Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif [J].

Dubin, MJ ;

Stokes, PH ;

Sum, EYM ;

Williams, RS ;

Valova, VA ;

Robinson, PJ ;

Lindeman, GJ ;

Glover, JNM ;

Visvader, JE ;

Matthews, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (26) :26932-26938

[8] A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein [J].

Foray, N ;

Marot, D ;

Gabriel, A ;

Randrianarison, V ;

Carr, AM ;

Perricaudet, M ;

Ashworth, A ;

Jeggo, P .

EMBO JOURNAL, 2003, 22 (11) :2860-2871

[9] Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature [J].

Furuta, Saori ;

Wang, Ju-Ming ;

Wei, Shuanzeng ;

Jeng, Yung-Ming ;

Jiang, Xianzhi ;

Gu, Bingnan ;

Chen, Phang-Lang ;

Lee, Eva Y. -H. P. ;

Lee, Wen-Hwa .

CANCER CELL, 2006, 10 (01) :13-24

[10] Molecular cloning and characterization of a novel retinoblastoma-binding protein [J].

Fusco, C ;

Reymond, A ;

Zervos, AS .

GENOMICS, 1998, 51 (03) :351-358

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