Asymmetric synthesis of macrolactin analogue

被引:20
作者
Kobayashi, Y
Fukuda, A
Kimachi, T
Ju-Ichi, M
Takemoto, Y [1 ]
机构
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan
[2] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan
关键词
macrolactin A; antibiotics; antivirus; asymmetric synthesis; ynone; isomerization; (E; E)-conjugated dienone;
D O I
10.1016/j.tetlet.2003.11.055
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Total asymmetric synthesis of macrolactin A analogue was accomplished by the convergent strategy. Rapid access to advanced intermediate 16 through isomerization of ynone to (E,E)-conjugated dienone is a key step of this synthesis. Overall, control of all of the four stereocenters was achieved by means of asymmetric and diastereoselective reactions without using any chiral natural sources. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:677 / 680
页数:4
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