Evolution of Staphylococcus aureus by large chromosomal replacements

被引：177

作者：

Robinson, DA ^{[1
]}

Enright, MC ^{[1
]}

机构：

[1] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

来源：

JOURNAL OF BACTERIOLOGY | 2004年 / 186卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/JB.186.4.1060-1064.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Conjugative transfer and replacement of hundreds of kilobases of a bacterial chromosome can occur in vitro, but replacements in nature are either an order of magnitude smaller or involve the movement of mobile genetic elements. We discovered that two lineages of Staphylococcus aureus, including a pandemic methicillin-resistant lineage, were founded by single chromosomal replacements of at least similar to244 and similar to557 kb representing similar to10 and similar to20% of the chromosome, respectively, without the obvious involvement of mobile genetic elements. The replacements are unprecedented in natural populations of bacteria because of their large size and unique structure and may have a dramatic impact on bacterial evolution.

引用

页码：1060 / 1064

页数：5

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