Application of LC/MS and related techniques to high-throughput drug discovery

被引：28

作者：

Espada, Alfonso ^{[1
]}

Molina-Martin, Manuel ^{[1
]}

Dage, Jeffrey ^{[2
]}

Kuo, Ming-Shang ^{[2
]}

机构：

[1] Ctr Invest Lilly SA, Analyt Technol Dept, Madrid 28108, Spain

[2] Lilly Res Labs, Analyt Technol, Indianapolis, IN 46285 USA

来源：

DRUG DISCOVERY TODAY | 2008年 / 13卷 / 9-10期

关键词：

D O I：

10.1016/j.drudis.2008.03.005

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The broad coordinated implementation of common platform technologies, such as LC/MS, can be a key factor in attaining increased throughput, sensitivity and data quality for pharmaceutical discovery. These platform technologies are the key tools that Medicinal Analytical Chemists rely upon to address the ever-changing needs of a drug discovery team. Despite the recent advances in key areas of sensitivity and speed for LC/MS, additional progress to address these never-ending analytical problems can be anticipated. This review will highlight current status and future advances for the applications of LC/MS and related techniques to high-throughput drug discovery.

引用

页码：417 / 423

页数：7

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