A RAVE about opioid withdrawal

被引：22

作者：

Alvarez, V ^{[1
]}

Arttamangkul, S

Williams, JT

机构：

[1] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

[2] Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97201 USA

来源：

NEURON | 2001年 / 32卷 / 05期

关键词：

D O I：

10.1016/S0896-6273(01)00530-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Control of trafficking of g protein-linked receptors is thought to be an important regulatory mechanism for receptor signaling. Finn and Whistler test the hypothesis that agonist-induced trafficking of opioid receptors regulates the development of tolerance and dependence. The results show that measures of tolerance and withdrawal to morphine are decreased under conditions where receptors are trafficked through the endocytic/recycling pathway.

引用

页码：761 / 763

页数：3

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