Phage mediated horizontal transfer of the sopE1 gene increases enteropathogenicity of Salmonella enterica serotype Typhimurium for calves

被引：42

作者：

Zhang, SP

Santos, RL

Tsolis, RM

Mirold, S

Hardt, WD

Adams, LG

Bäumler, AJ

机构：

[1] Texas A&M Univ, Syst Hlth Sci Ctr, Coll Med, Dept Med Microbiol & Immunol, College Stn, TX 77843 USA

[2] Texas A&M Univ, Coll Vet Med, Dept Vet Pathobiol, College Stn, TX 77843 USA

[3] Max Von Pettenkofer Inst, D-80336 Munich, Germany

[4] Swiss Fed Inst Technol, Inst Microbiol, CH-8092 Zurich, Switzerland

来源：

FEMS MICROBIOLOGY LETTERS | 2002年 / 217卷 / 02期

关键词：

enteritis; type III secretion; bacteriophage; horizontal gene transfer; Salmonella;

D O I：

10.1111/j.1574-6968.2002.tb11482.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Epidemiological evidence shows that the sopE1 gene is associated with Salmonella Typhimurium phage types causing epidemics in cattle. In this study we demonstrate that horizontal transfer of the sopE1 gene by lysogenic conversion with the SopEPhi increased enteropathogenicity of S. Typhimurium in the bovine ligated ileal loop model. These data support the hypothesis that phage mediated horizontal transfer of the sopE1 gene contributes to the emergence of epidemic cattle-associated S. Typhimurium clones. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

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页码：243 / 247

页数：5

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