A dynamical study of antibody-antigen encounter reactions

被引:15
作者
Bongini, Lorenzo
Fanelli, Duccio
Piazza, Francesco
De Los Rios, Paolo
Sanner, Michel
Skoglund, Ulf
机构
[1] Univ Florence, Dipartimento Fis, I-50019 Florence, Italy
[2] Univ Manchester, Sch Phys & Astron, Theoret Phys Grp, Manchester, Lancs, England
[3] Ecole Polytech Fed Lausanne, Inst Theoret Phys, SB, ITP,LBS, CH-1015 Lausanne, Switzerland
[4] SCRIPPS, La Jolla, CA 92037 USA
[5] Karolinska Inst, Dept Cell & Mol Biol, S-17171 Stockholm, Sweden
关键词
DIFFUSION-CONTROLLED REACTIONS; MOLECULAR-DYNAMICS; BINDING; COAGULATION; KINETICS; ENERGY; MODE;
D O I
10.1088/1478-3975/4/3/004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The effects of internal dynamics in diffusion-driven encounters between macro-molecules represent a problem of broad relevance in molecular biology. In this view, we investigate a typical antigen-antibody reaction chain, based on a coarse-grained mechanical model parameterized directly upon results from single-molecule experiments. We demonstrate that the internal dynamics is a crucial factor in the encounter process. To describe our numerical results, we formulate a simple, intuitive theoretical framework, and we develop it analytically. This enables us to show that the inner dynamics of antibody molecules results in a cooperative behavior of their individual sub-units. Along the same lines, we also investigate the case of double binding to multi-valent antigens. Our results quantify the enhancement of avidity afforded by the double binding in excellent agreement with the available experimental data.
引用
收藏
页码:172 / 180
页数:9
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