Functionalized bimodal mesoporous silicas as carriers for controlled aspirin delivery

被引：98

作者：

Gao, Lin ^{[1
]}

Sun, Jihong ^{[1
]}

Li, Yuzhen ^{[1
]}

机构：

[1] Beijing Univ Technol, Dept Chem & Chem Engn, Coll Environm & Energy Engn, Beijing 100124, Peoples R China

来源：

JOURNAL OF SOLID STATE CHEMISTRY | 2011年 / 184卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Bimodal mesoporous silicas; Aspirin; Controlled release; Functionalization; RESPONSIVE CONTROLLED-RELEASE; DRUG-DELIVERY; PORE-SIZE; MCM-41; NANOPARTICLES; MORPHOLOGY; IBUPROFEN; SYSTEM; SBA-15;

D O I：

10.1016/j.jssc.2011.05.052

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学];

摘要：

The bimodal mesoporous silica modified with 3-aminopropyltriethoxysilane was performed as the aspirin carrier. The samples' structure, drug loading and release profiles were characterized with X-ray diffraction, scanning electron microscopy, N-2 adsorption and desorption, Fourier transform infrared spectroscopy, TG analysis, elemental analysis and UV-spectrophotometer. For further exploring the effects of the bimodal mesopores on the drug delivery behavior, the unimodal mesoporous material MCM-41 was also modified as the aspirin carrier. Meantime, Korsmeyer-Peppas equation f(t) = kt(n) was employed to analyze the dissolution data in details. It is indicated that the bimodal mesopores are beneficial for unrestricted drug molecules diffusing and therefore lead to a higher loading and faster releasing than that of MCM-41. The results show that the aspirin delivery properties are influenced considerably by the mesoporous matrix, whereas the large pore of bimodal mesoporous silica is the key point for the improved controlled-release properties. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1909 / 1914

页数：6

共 39 条

[1]

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