Deciphering the model pathogenic fungus Cryptococcus neoformans

被引：253

作者：

Idnurm, A ^{[1
]}

Bahn, YS ^{[1
]}

Nielsen, K ^{[1
]}

Lin, XR ^{[1
]}

Fraser, JA ^{[1
]}

Heitman, J ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2005年 / 3卷 / 10期

关键词：

D O I：

10.1038/nrmicro1245

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cryptococcus neoformans is a basidiomycete fungal pathogen of humans that has diverged considerably from other model fungi such as Neurospora crassa, Aspergillus nidulans, Saccharomyces cerevisiae and the common human fungal pathogen Candida albicans. The recent completion of the genome sequences of two related C. neoformans strains and the ongoing genome sequencing of three other divergent Cryptococcus strains with different virulence phenotypes and environmental distributions should improve our understanding of this important pathogen. We discuss the biology of C. neoformans in light of this genomic data, with a special emphasis on the role that evolution and sexual reproduction have in the complex relationships of the fungus with the environment and the host.

引用

页码：753 / 764

页数：12

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