Arc in synaptic plasticity: from gene to behavior

被引：282

作者：

Korb, Erica ^{[1
,2
,3
]}

Finkbeiner, Steven ^{[1
,2
,3
,4
]}

机构：

[1] Gladstone Inst Neurol Dis, San Francisco, CA USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[3] Univ Calif San Francisco, Dept Physiol, San Francisco, CA USA

[4] Taube Koret Ctr Huntingtons Dis Res, San Francisco, CA USA

来源：

TRENDS IN NEUROSCIENCES | 2011年 / 34卷 / 11期

关键词：

IMMEDIATE-EARLY GENE; LONG-TERM POTENTIATION; CYTOSKELETAL-ASSOCIATED PROTEIN; SERUM RESPONSE FACTOR; MESSENGER-RNA INDUCTION; DENTATE GYRUS; ACTIN POLYMERIZATION; RAT HIPPOCAMPUS; ARC/ARG3.1; EXPRESSION;

D O I：

10.1016/j.tins.2011.08.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The activity-regulated cytoskeletal (Arc) gene encodes a protein that is critical for memory consolidation. Arc is one of the most tightly regulated molecules known: neuronal activity controls Arc mRNA induction, trafficking and accumulation, and Arc protein production, localization and stability. Arc regulates synaptic strength through multiple mechanisms and is involved in essentially every known form of synaptic plasticity. It also mediates memory formation and is implicated in multiple neurological diseases. In this review, we will discuss how Arc is regulated and used as a tool to study neuronal activity. We will also attempt to clarify how its molecular functions correspond to its requirement in various forms of plasticity, discuss Arc's role in behavior and disease, and highlight critical unresolved questions.

引用

收藏

页码：591 / 598

页数：8

相关论文

共 83 条

[11] Arc mRNA induction in striatal efferent neurons associated with response learning [J].

Daberkow, D. P. ;

Riedy, M. D. ;

Kesner, R. P. ;

Keefe, K. A. .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2007, 26 (01) :228-241

[12] The actin cytoskeleton: Integrating form and function at the synapse [J].

Dillon, C ;

Goda, Y .

ANNUAL REVIEW OF NEUROSCIENCE, 2005, 28 :25-55

[13] Dynamics of bidirectional transport of Arc mRNA in neuronal dendrites [J].

Dynes, Joseph L. ;

Steward, Oswald .

JOURNAL OF COMPARATIVE NEUROLOGY, 2007, 500 (03) :433-447

[14] Experience-dependent structural plasticity in the cortex [J].

Fu, Min ;

Zuo, Yi .

TRENDS IN NEUROSCIENCES, 2011, 34 (04) :177-187

[15] Arc interacts with microtubules/microtubule-associated protein 2 and attenuates microtubule-associated protein 2 immunoreactivity in the dendrites [J].

Fujimoto, T ;

Tanaka, H ;

Kumamaru, E ;

Okamura, K ;

Miki, N .

JOURNAL OF NEUROSCIENCE RESEARCH, 2004, 76 (01) :51-63

[16] A Specific Requirement of Arc/Arg3.1 for Visual Experience-Induced Homeostatic Synaptic Plasticity in Mouse Primary Visual Cortex [J].

Gao, Ming ;

Sossa, Kenneth ;

Song, Lihua ;

Errington, Lauren ;

Cummings, Laurel ;

Hwang, Hongik ;

Kuhl, Dietmar ;

Worley, Paul ;

Lee, Hey-Kyoung .

JOURNAL OF NEUROSCIENCE, 2010, 30 (21) :7168-7178

[17] Multiplexed dendritic targeting of α calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein RNAs by the A2 pathway [J].

Gao, Yuanzheng ;

Tatavarty, Vedakumar ;

Korza, George ;

Levin, Mikhail K. ;

Carson, John H. .

MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (05) :2311-2327

[18] The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression [J].

Giorgi, Corinna ;

Yeo, Gene W. ;

Stone, Martha E. ;

Katz, Donald B. ;

Burge, Christopher ;

Turrigiano, Gina ;

Moore, Melissa J. .

CELL, 2007, 130 (01) :179-191

[19] Autism genome-wide copy number variation reveals ubiquitin and neuronal genes [J].

Glessner, Joseph T. ;

Wang, Kai ;

Cai, Guiqing ;

Korvatska, Olena ;

Kim, Cecilia E. ;

Wood, Shawn ;

Zhang, Haitao ;

Estes, Annette ;

Brune, Camille W. ;

Bradfield, Jonathan P. ;

Imielinski, Marcin ;

Frackelton, Edward C. ;

Reichert, Jennifer ;

Crawford, Emily L. ;

Munson, Jeffrey ;

Sleiman, Patrick M. A. ;

Chiavacci, Rosetta ;

Annaiah, Kiran ;

Thomas, Kelly ;

Hou, Cuiping ;

Glaberson, Wendy ;

Flory, James ;

Otieno, Frederick ;

Garris, Maria ;

Soorya, Latha ;

Klei, Lambertus ;

Piven, Joseph ;

Meyer, Kacie J. ;

Anagnostou, Evdokia ;

Sakurai, Takeshi ;

Game, Rachel M. ;

Rudd, Danielle S. ;

Zurawiecki, Danielle ;

McDougle, Christopher J. ;

Davis, Lea K. ;

Miller, Judith ;

Posey, David J. ;

Michaels, Shana ;

Kolevzon, Alexander ;

Silverman, Jeremy M. ;

Bernier, Raphael ;

Levy, Susan E. ;

Schultz, Robert T. ;

Dawson, Geraldine ;

Owley, Thomas ;

McMahon, William M. ;

Wassink, Thomas H. ;

Sweeney, John A. ;

Nurnberger, John I., Jr. ;

Coon, Hilary .

NATURE, 2009, 459 (7246) :569-573

[20] The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc [J].

Greer, Paul L. ;

Hanayama, Rikinari ;

Bloodgood, Brenda L. ;

Mardinly, Alan R. ;

Lipton, David M. ;

Flavell, Steven W. ;

Kim, Tae-Kyung ;

Griffith, Eric C. ;

Waldon, Zachary ;

Maehr, Rene ;

Ploegh, Hidde L. ;

Chowdhury, Shoaib ;

Worley, Paul F. ;

Steen, Judith ;

Greenberg, Michael E. .

CELL, 2010, 140 (05) :704-716

← 1 2 3 4 5 6 7 8 9 →