Epidemiological and clinical consequences of within-host evolution

被引:75
作者
Alizon, Samuel [1 ,2 ]
Luciani, Fabio [3 ]
Regoes, Roland R. [4 ]
机构
[1] CNRS, Lab Genet & Evolut Malad Infect, UMR, F-34394 Montpellier 5, France
[2] Inst Rech Dev IRD 2724, F-34394 Montpellier 5, France
[3] Univ New S Wales, Fac Med, Sch Med Sci, Infect & Inflammat Res Ctr, Sydney, NSW 2052, Australia
[4] ETH, Inst Integrat Biol, CH-8092 Zurich, Switzerland
关键词
IMMUNODEFICIENCY-VIRUS TYPE-1; GENETIC DIVERSITY; VIRAL EVOLUTION; HIV-INFECTION; DYNAMICS; ESCAPE; SELECTION; FITNESS; VIRULENCE; MUTATION;
D O I
10.1016/j.tim.2010.09.005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Many viruses and bacteria are known to evolve rapidly over the course of an infection. However, epidemiological studies generally assume that within-host evolution is an instantaneous process. We argue that the dynamics of within-host evolution has implications at the within-host and at the between-host levels. We first show that epidemiologists should consider within-host evolution, notably because it affects the genotype of the pathogen that is transmitted. We then present studies that investigate evolution at the within-host level and examine the extent to which these studies can help to understand infection traits involved in the epidemiology (e.g. transmission rate, virulence, recovery rate). Finally, we discuss how new techniques for data acquisition can open new perspectives for empirical and theoretical research.
引用
收藏
页码:24 / 32
页数:9
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