(-)3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: A dual PPAR agonist with potent antihyperglycemic and lipid modulating activity

被引：141

作者：

Lohray, BB

Lohray, VB

Bajji, AC

Kalchar, S

Poondra, RR

Padakanti, S

Chakrabarti, R

Vikramadithyan, RK

Misra, P

Juluri, S

Mamidi, NVSR

Rajagopalan, R

机构：

[1] Dr Reddys Res Fdn, Discovery Synth, Hyderabad 500016, Andhra Pradesh, India

[2] Dr Reddys Res Fdn, Discovery Biol, Hyderabad 500016, Andhra Pradesh, India

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2001年 / 44卷 / 16期

关键词：

D O I：

10.1021/jm010143b

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(-)DRF 2725 (6) is a phenoxazine analogue of phenyl propanoic acid. Compound 6 showed interesting dual activation of PPAR alpha and PPAR gamma. In insulin resistant db/db mice, 6 showed better reduction of plasma glucose and triglyceride levels as compared to rosiglitazone. Compound 6 has also shown good oral bioavailability and impressive pharmacokinetic characteristics. Our study indicates that 6 has great potential as a drug for diabetes and dyslipidemia.

引用

页码：2675 / 2678

页数：4

共 11 条

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