T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites

被引：166

作者：

Cueni, Lucius ^{[1
]}

Canepari, Marco ^{[1
]}

Lujan, Rafael ^{[2
]}

Emmenegger, Yann ^{[3
]}

Watanabe, Masahiko ^{[4
]}

Bond, Chris T. ^{[5
]}

Franken, Paul ^{[3
]}

Adelman, John P. ^{[5
]}

Luthi, Anita ^{[1
,6
]}

机构：

[1] Univ Basel, Div Pharmacol & Neurobiol Biozentrum, CH-4056 Basel, Switzerland

[2] Univ Castilla La Mancha, Crib Fac Med, Dept Ciencias Med, Albacete 02006, Spain

[3] Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland

[4] Hokkaido Univ, Sch Med, Dept Anat, Kita Ku, Sapporo, Hokkaido 0608638, Japan

[5] Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97201 USA

[6] Univ Lausanne, Fac Biol & Med, Dept Cell Biol & Morphol, CH-1005 Lausanne, Switzerland

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nn.2124

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

T-type Ca2+ channels (T channels) underlie rhythmic burst discharges during neuronal oscillations that are typical during sleep. However, the Ca2+-dependent effectors that are selectively regulated by T currents remain unknown. We found that, in dendrites of nucleus reticularis thalami (nRt), intracellular Ca2+ concentration increases were dominated by Ca2+ influx through T channels and shaped rhythmic bursting via competition between Ca2+-dependent small-conductance (SK)-type K1 channels and Ca2+ uptake pumps. Oscillatory bursting was initiated via selective activation of dendritically located SK2 channels, whereas Ca2+ sequestration by sarco/endoplasmic reticulum Ca2+-ATPases (SERCAs) and cumulative T channel inactivation dampened oscillations. Sk2(-/-) (also known as Kcnn2) mice lacked cellular oscillations, showed a greater than threefold reduction in low-frequency rhythms in the electroencephalogram of non-rapid-eye-movement sleep and had disrupted sleep. Thus, the interplay of T channels, SK2 channels and SERCAs in nRt dendrites comprises a specialized Ca2+ signaling triad to regulate oscillatory dynamics related to sleep.

引用

页码：683 / 692

页数：10

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