Changes in hippocampal SNAP-25 expression following afferent lesions

被引：8

作者：

Ramírez, MJ

Honer, WG

Minger, SL

Francis, PT

机构：

[1] Univ Navarra, Sch Med, Dept Pharmacol, Pamplona 31008, Spain

[2] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada

[3] Kings Coll London, GKT, Sch Biomed Sci, Dementia Res Lab,Neurosci Res Ctr, London SE1 1UL, England

来源：

BRAIN RESEARCH | 2004年 / 997卷 / 01期

基金：

加拿大健康研究院;

关键词：

synaptic protein; entorhinal cortex lesion; 192-IgG saporin; rat; reinnervation after lesions;

D O I：

10.1016/j.brainres.2003.10.045

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Reductions in SNAP-25 immunohistochemistry were found after removing the glutamatergic and cholinergic inputs to the rat hippocampus. SNAP-25 levels were normalised by 1 month after afferent lesions. Surprisingly, a superimposed cholinergic lesions did not affect the return to normal SNAP-25 levels after a long-term entorhinal cortex lesion. It is concluded that changes in SNAP-25 may represent early markers of synaptic loss following afferent lesions to the hippocampus. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：133 / 135

页数：3

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