Immune suppression in the tumor microenvironment: a role for dendritic cell-mediated tolerization of T cells

被引：128

作者：

Hurwitz, Arthur A. ^{[1
]}

Watkins, Stephanie K. ^{[1
]}

机构：

[1] NCI, Tumor Immun & Tolerance Sect, Mol Immunoregulat Lab, Canc & Inflammat Program, Frederick, MD 21702 USA

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2012年 / 61卷 / 02期

关键词：

Tumor microenvironment; T cell; Tolerance; Suppression; CITIM; 2011; PROSTATIC TUMORS; CUTTING EDGE; MAST-CELLS; TOLERANCE; ACTIVATION; CANCER;

D O I：

10.1007/s00262-011-1181-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Immune suppression remains a consistent obstacle to successful anti-tumor immune responses. As tumors develop, they create a microenvironment that not only supports tumor growth and metastasis but also reduces potential adaptive immunity to tumor antigens. Among the many components of this tumor microenvironment is a population of dendritic cells which exert profound immune suppressive effects on T cells. In this review, we discuss our recent findings related to these tumor-associated dendritic cells and how targeting them may serve to generate more durable anti-tumor immune responses.

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收藏

页码：289 / 293

页数：5

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