Complexation study and anticellular activity enhancement by doxorubicin-cyclodextrin complexes on a multidrug-resistant adenocarcinoma cell line

被引：37

作者：

Al-Omar, A

Abdou, S

De Robertis, L

Marsura, A

Finance, C

机构：

[1] Univ Nancy 1, Fac Sci Pharmaceut & Biol, CNRS, UMR, F-54001 Nancy, France

[2] Ctr Etud & Rech Macromol Vegetales, CNRS, UPR 5301, F-38041 Grenoble 9, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(99)00150-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ability of molecular complexes of [Doxorubicin (DX)-cyclodextrin (Cd)] to enhance the anticellular activity of antineoplasic drug Doxorubicin and to reverse its multidrug resistance has been investigated. A spectroscopic study of the alpha,beta, and gamma-[DX-Cds] complexes has been investigated in relation to their biological effects on a multidrug resistant (MDR) human rectal adenocarcinoma cell line (HRT-18). A ten fold enhancement of DX anticellular activity in presence of beta-cyclodextrin alone was detected, (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1115 / 1120

页数：6

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