A phytochemical in the edible Tamogi-take mushroom (Pleurotus cornucopiae), D-mannitol, inhibits ACE activity and lowers the blood pressure of spontaneously hypertensive rats

被引:61
作者
Hagiwara, S
Takahashi, M
Shen, YB
Kaihou, S
Tomiyama, T
Yazawa, M
Tamai, Y
Sin, Y
Kazusaka, A
Terazawa, M [1 ]
机构
[1] Three B Co Inc, Nanporo 0690238, Japan
[2] Hokkaido Univ, Grad Sch Agr, Div Environm Resources, Res Grp Forest Resource Sci, Sapporo, Hokkaido 0608589, Japan
[3] Hokkaido Univ, Grad Sch Sci, Div Chem, Sapporo, Hokkaido 0600810, Japan
[4] Adv Technol Co Ltd, Sapporo, Hokkaido 0068585, Japan
关键词
angiotensin I converting enzyme (ACE) inhibitor; antihypertensive effect; D-mannitol; Tamogi-take; spontaneously hypertensive rat;
D O I
10.1271/bbb.69.1603
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
D-Mannitol, one of the main phytochemicals of the edible Tamogi-take mushroom (Pleurotus cornucopiae), was found to inhibit an angiotensin I converting enzyme (ACE). The antihypertensive effect of D-mannitol and a hot water extract of Tamogi-take mushroom was demonstrated in spontaneously hypertensive rats (SHR) by oral administration.
引用
收藏
页码:1603 / 1605
页数:3
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