International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-Activated Chloride Channels

被引：149

作者：

Huang, Fen ^{[1
]}

Wong, Xiuming ^{[1
]}

Jan, Lily Y. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Physiol, San Francisco, CA 94158 USA

来源：

PHARMACOLOGICAL REVIEWS | 2012年 / 64卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CA2+-ACTIVATED CL-CHANNELS; SMOOTH-MUSCLE-CELLS; GASTROINTESTINAL STROMAL TUMORS; OLFACTORY SENSORY NEURONS; GENOME-WIDE ASSOCIATION; INTERSTITIAL-CELLS; TRANSMEMBRANE PROTEIN; MEMBRANE-PROTEIN; MOLECULAR-BASIS; GLAND ACINAR;

D O I：

10.1124/pr.111.005009

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and implicated in physiological processes such as sensory transduction, epithelial secretion, and smooth muscle contraction. Transmembrane proteins with unknown function 16 (TMEM16A) has recently been identified as a major component of CaCCs. Detailed molecular analysis of TMEM16A will be needed to understand its structure-function relationships. The role this channel plays in physiological systems remains to be established and is currently a subject of intense investigation.

引用

页码：1 / 15

页数：15

共 146 条

[1]

Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea [J].

Agnel, M ;

Vermat, T ;

Culouscou, JM .

FEBS LETTERS, 1999, 455 (03) :295-301

[2]

Expression of three distinct families of calcium-activated chloride channel genes in the mouse dorsal root ganglion [J].

Al-Jumaily M. ;

Kozlenkov A. ;

Mechaly I. ;

Fichard A. ;

Matha V. ;

Scamps F. ;

Valmier J. ;

Carroll P. .

Neuroscience Bulletin, 2007, 23 (5) :293-299

[3]

Bovine pancreatic duct cells express cAMP- and Ca2+-activated apical membrane Cl- conductances [J].

AlNakkash, L ;

Cotton, CU .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1997, 273 (01) :G204-G216

[4]

CALCIUM AND CAMP ACTIVATE DIFFERENT CHLORIDE CHANNELS IN THE APICAL MEMBRANE OF NORMAL AND CYSTIC-FIBROSIS EPITHELIA [J].

ANDERSON, MP ;

WELSH, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (14) :6003-6007

[5]

Axotomy-induced expression of calcium-activated chloride current in subpopulations of mouse dorsal root ganglion neurons [J].

André, S ;

Boukhaddaoui, H ;

Campo, B ;

Al-Jumaily, M ;

Mayeux, V ;

Greuet, D ;

Valmier, J ;

Scamps, F .

JOURNAL OF NEUROPHYSIOLOGY, 2003, 90 (06) :3764-3773

[6]

Mechanism of the inhibition of Ca2+-activated Cl- currents by phosphorylation in pulmonary arterial smooth muscle cells [J].

Angermann, Jeff E. ;

Sanguinetti, Amy R. ;

Kenyon, James L. ;

Leblanc, Normand ;

Greenwood, Iain A. .

JOURNAL OF GENERAL PHYSIOLOGY, 2006, 128 (01) :73-87

[7]

Complex Phosphatase Regulation of Ca2+-activated Cl- Currents in Pulmonary Arterial Smooth Muscle Cells [J].

Ayon, Ramon ;

Sones, William ;

Forrest, Abigail S. ;

Wiwchar, Michael ;

Valencik, Maria L. ;

Sanguinetti, Amy R. ;

Perrino, Brian A. ;

Greenwood, Iain A. ;

Leblanc, Normand .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (47) :32507-32521

[8]

VOLTAGE-ACTIVATED AND CALCIUM-ACTIVATED CURRENTS STUDIED IN SOLITARY ROD INNER SEGMENTS FROM THE SALAMANDER RETINA [J].

BADER, CR ;

BERTRAND, D ;

SCHWARTZ, EA .

JOURNAL OF PHYSIOLOGY-LONDON, 1982, 331 (OCT) :253-+

[9]

A close association of RyRs with highly dense clusters of Ca2+-activated Cl- channels underlies the activation of STICs by Ca2+ sparks in mouse airway smooth muscle [J].

Bao, Rongfeng ;

Lifshitz, Lawrence M. ;

Tuft, Richard A. ;

Bellve, Karl ;

Fogarty, Kevin E. ;

ZhuGe, Ronghua .

JOURNAL OF GENERAL PHYSIOLOGY, 2008, 132 (01) :145-160

[10]

PACEMAKER ACTIVITY RECORDED IN INTERSTITIAL-CELLS OF CAJAL OF THE GASTROINTESTINAL-TRACT [J].

BARAJASLOPEZ, C ;

BEREZIN, I ;

DANIEL, EE ;

HUIZINGA, JD .

AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (04) :C830-C835

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