CO-opting the host HO-1 pathway in tuberculosis and malaria

被引：7

作者：

Sinnis, Photini ^{[1
]}

Ernst, Joel D. ^{[2
]}

机构：

[1] NYU, Sch Med, Dept Med Parasitol, New York, NY 10010 USA

[2] NYU, Sch Med, Div Infect Dis, Dept Med, New York, NY 10016 USA

来源：

CELL HOST & MICROBE | 2008年 / 3卷 / 05期

关键词：

D O I：

10.1016/j.chom.2008.04.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

Infection with Mycobacterium tuberculosis and Plasmodium species results in upregulation of the host heme oxygenase-1 pathway. In tuberculosis infection, this leads to upregulation of the bacterial "dormancy regulon," whereas in malaria, it enhances the efficiency with which sporozoites develop into exoerythrocytic stages. Here we discuss these findings as well as some of the interesting questions they raise.

引用

页码：277 / 279

页数：3

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