The biological function of allergens: Relevant for the induction of allergic diseases?

被引：37

作者：

Bufe, A ^{[1
]}

机构：

[1] Forschungszentrum Borstel, D-23845 Borstel, Germany

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1998年 / 117卷 / 04期

关键词：

allergens; IgE epitopes; T cell epitopes; biological function; enzyme activity; allergic inflammation; structure; CD23; CD25;

D O I：

10.1159/000024013

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

During the last 10 years an increasing number of allergens were identified and biochemically as well as immunologically characterized. More and more information on the primary structure of these molecules, revealed by recombinant technologies, became available. Furthermore for several allergens the biological functions could be elucidated. Most recently it was shown that beside IgE-binding capacity functional properties such as enzyme activity may contribute to the allergenicity and the induction of allergic inflammation. These findings could stimulate novel concepts in allergy prevention and therapy. This review summarizes recent data in this area.

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页码：215 / 219

页数：5

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