Molecular characterization and sequence analysis of human astroviruses circulating in Hungary

被引：16

作者：

Jakab, F

Walter, JE

Berke, T

Matson, DO

Mitchell, DK

Szucs, G

机构：

[1] Baranya Cty Inst State Publ Hlth Serv, Reg Lab Virol, H-7623 Pecs, Hungary

[2] Childrens Hosp Kings Daughters, Eastern Virginia Med Sch, Ctr Pediat Res, Norfolk, VA USA

[3] Univ Pecs, Fac Med, Dept Med Microbiol & Immunol, Pecs, Hungary

来源：

FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2003年 / 39卷 / 02期

关键词：

human astrovirus; molecular sequence analysis; genotype;

D O I：

10.1016/S0928-8244(03)00236-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human astroviruses (HAstVs) are major pathogens in viral gastroenteritis worldwide. Twenty-five HAstV strains were detected from stool specimens of children hospitalized for acute gastroenteritis in Budapest, Hungary, between 1995 and 1999. Sequence analysis was performed at the 3' end of the capsid gene to determine genotypic diversity of HAstVs circulating in Hungary. Five different genotypes of HAstVs were identified: HAstV-1 was predominant, followed by types 5, 8, 3 and 4. Two different subtypes of HAstV-1 were detected, but only one at a time in the community. This is the first report on the genetic diversity of HAstVs in Hungary and Central/Eastern Europe. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：97 / 102

页数：6

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