Characterization of antibody responses to annual influenza vaccination over four years in a healthy elderly population

被引:45
作者
Gardner, EM
Bernstein, ED
Dran, S
Munk, G
Gross, P
Abrutyn, E
Murasko, DM
机构
[1] Med Coll Penn & Hahnemann Univ, Sch Med, Dept Microbiol & Immunol, Philadelphia, PA 19129 USA
[2] Hackensack Univ, Med Ctr, Dept Internal Med, Hackensack, NJ 07601 USA
[3] Med Coll Penn & Hahnemann Univ, Sch Med, Dept Med, Philadelphia, PA 19129 USA
[4] Med Coll Penn & Hahnemann Univ, Sch Publ Hlth, Dept Med, Philadelphia, PA 19129 USA
关键词
influenza vaccination; humoral; elderly;
D O I
10.1016/S0264-410X(01)00246-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The effects of yearly influenza immunization on the level of antibody responses were assessed in 92 healthy elderly subjects immunized over four contiguous years (1993-1996) with a trivalent influenza vaccine that included A/Texas annually. Anti-Al Texas antibodies increased significantly and similarly post-vaccination each year, but returned to comparable baseline levels annually. Percentages of subjects with anti-A/Texas titers greater than or equal to 40 post-vaccination were comparable over four years. Importantly, post-vaccination titers greater than or equal to 40 to A/Texas in 1993 -1994 predicted anti-A/Texas titers greater than or equal to 40 in subsequent years. Thirty percent of individuals produced four-fold rises to any vaccine component the first year it was included in the vaccine, however, this percentage decreased to about 10% after subsequent vaccination with the same component. This study clearly supports the concept that annual immunization with the same influenza vaccine component over multiple years does not significantly decrease antibody titers in a healthy elderly population. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:4610 / 4617
页数:8
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