Antiphospholipid syndromes in infectious diseases

Antiphospholipid antibodies are essential in the diagnosis of antiphospholipid syndrome (APS), or the classic "Hughes syndrome," which is a systemic disorder that is autoimmune in nature. They are also found in various infections in low titers without any evidence of thrombotic manifestations of APS. However, in a few infections, when antiphospholipid antibodies are associated with protein cofactor, there can be associated thrombosis. Different infections are also responsible for triggering a subset of lethal APS, acute catastrophic APS. This situation requires prompt diagnosis and aggressive treatment of the infection to prevent severe complications.