Blood infectivity, processing and screening tests in transmissible spongiform encephalopathy

被引：52

作者：

Brown, P

机构：

[1] Bethesda, MD 20814

来源：

VOX SANGUINIS | 2005年 / 89卷 / 02期

关键词：

blood screening tests; Creutzfeldt-Jakob disease; prion protein; prion; scrapie; transmissible spongiform encephalopathy;

D O I：

10.1111/j.1423-0410.2005.00683.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Surprising advances have been made in the areas of blood infectivity, infectivity removal and, especially, blood screening tests for transmissible spongiform encephalopathy (TSE) in the past few years. In fact, if anyone as recently as last year had suggested that a screening test for preclinical human infection might be available before the end of 2005, the statement would have been met with smiling disbelief. Nevertheless, it can be confidently predicted that the diagnostic misfolded 'prion' protein (PrPTSE) will soon be reliably detectable in blood during the symptomatic phase of disease, and it is highly probable that it will also be detectable in blood from at least a proportion of infected individuals during the preclinical phase of disease.

引用

收藏

页码：63 / 70

页数：8

相关论文

共 26 条

[11] Transmission of prion diseases by blood transfusion [J].

Hunter, N ;

Foster, J ;

Chong, A ;

McCutcheon, S ;

Parnham, D ;

Eaton, S ;

MacKenzie, C ;

Houston, F .

JOURNAL OF GENERAL VIROLOGY, 2002, 83 :2897-2905

[12] A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions [J].

Klöhn, PC ;

Stoltze, L ;

Flechsig, E ;

Enari, M ;

Weissmann, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (20) :11666-11671

[13] CELL-FREE FORMATION OF PROTEASE-RESISTANT PRION PROTEIN [J].

KOCISKO, DA ;

COME, JH ;

PRIOLA, SA ;

CHESEBRO, B ;

RAYMOND, GJ ;

LANSBURY, PT ;

CAUGHEY, B .

NATURE, 1994, 370 (6489) :471-474

[14] CREUTZFELDT-JAKOB DISEASE IN MICE - PERSISTENT VIREMIA AND PREFERENTIAL REPLICATION OF VIRUS IN LOW-DENSITY LYMPHOCYTES [J].

KURODA, Y ;

GIBBS, CJ ;

AMYX, HL ;

GAJDUSEK, DC .

INFECTION AND IMMUNITY, 1983, 41 (01) :154-161

[15] Polymeric ligands with specificity for aggregated prion proteins [J].

Lane, A ;

Stanley, CJ ;

Dealler, S ;

Wilson, SM .

CLINICAL CHEMISTRY, 2003, 49 (10) :1774-1775

[16] A direct relationship between the partitioning of the pathogenic prion protein and transmissible spongiform encephalopathy infectivity during the purification of plasma proteins [J].

Lee, DC ;

Stenland, CJ ;

Miller, JLC ;

Cai, K ;

Ford, EK ;

Gilligan, KJ ;

Hartwell, RC ;

Terry, JC ;

Rubenstein, R ;

Fournel, M ;

Petteway, SR .

TRANSFUSION, 2001, 41 (04) :449-455

[17] Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion [J].

Llewelyn, CA ;

Hewitt, PE ;

Knight, RSG ;

Amar, K ;

Cousens, S ;

Mackenzie, J ;

Will, RG .

LANCET, 2004, 363 (9407) :417-421

[18] Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient [J].

Peden, AH ;

Head, MW ;

Ritchie, DL ;

Bell, JE ;

Ironside, JW .

LANCET, 2004, 364 (9433) :527-529

[19] Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding [J].

Saborio, GP ;

Permanne, B ;

Soto, C .

NATURE, 2001, 411 (6839) :810-813

[20] Eight prion strains have PrPSc molecules with different conformations [J].

Safar, J ;

Wille, H ;

Itrri, V ;

Groth, D ;

Serban, H ;

Torchia, M ;

Cohen, FE ;

Prusiner, SB .

NATURE MEDICINE, 1998, 4 (10) :1157-1165