GABA signalling during development:: new data and old questions

被引：114

作者：

Varju, P

Katarova, Z

Madarász, E

Szabó, G

机构：

[1] Hungarian Acad Sci, Inst Expt Med, Lab Mol Biol & Genet, H-1083 Budapest, Hungary

[2] Hungarian Acad Sci, Inst Expt Med, Lab Neural Cell Biol, Budapest, Hungary

[3] Eotvos Lorand Univ, Dept Physiol & Neurobiol, Budapest, Hungary

来源：

CELL AND TISSUE RESEARCH | 2001年 / 305卷 / 02期

关键词：

GAD; embryonic development; neuronal differentiation; trophic action;

D O I：

10.1007/s004410100356

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In addition to being the major inhibitory neurotransmitter, gamma -aminobutyric acid (GABA) is thought to play a morphogenetic role in embryonic development. During the last decade, considerable progress has been made in elucidating the molecular mechanisms involved in GABA synthesis and biological action. The present review is an attempt to summarise recent results on the ontogeny of the different components of embryonic GABA signalling with an emphasis on the synthesis of GABA by different molecular forms of glutamic acid decarboxylase (GAD).

引用

页码：239 / 246

页数：8

共 89 条

[21] Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67 [J].