In vitro gene delivery by pDNA/chitosan complexes coated with anionic PEG derivatives that have a sugar side chain

被引：11

作者：

Hashimoto, Mayu ^{[1
]}

Koyama, Yoshiyuki ^{[2
]}

Sato, Toshinori ^{[1
]}

机构：

[1] Keio Univ, Fac Sci & Technol, Kouhoku Ku, Yokohama, Kanagawa 2238522, Japan

[2] Otsuma Womens Univ, Dept Home Econ, Chiyoda Ku, Tokyo 1028357, Japan

来源：

CHEMISTRY LETTERS | 2008年 / 37卷 / 03期

关键词：

D O I：

10.1246/cl.2008.266

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We developed pDNA/chitosan complexes coated with sugar-modified PEG-A/Cs, which are poly(ethylene glycol) derivatives with a side chain of carboxylic acid and sugar. The cationic pDNA/chitosan complexes were coated with anionic sugar-modified PEG-Cs, and anionic ternary complexes were formed. Coating the pDNA/chitosan complexes with maltoseor lactose-modified PEG-A/C (Mal-PEG-A/C or Lac-PEG-A/C, respectively) greatly promoted their stability in water and transfection efficiency in vitro.

引用

页码：266 / 267

页数：2

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