Immunohistopathologic diagnosis of epidermolysis bullosa

被引:20
作者
Bergman, R
机构
[1] Rambam Med Ctr, Dept Dermatol, IL-31096 Haifa, Israel
[2] Rambam Med Ctr, Dept Pathol, IL-31096 Haifa, Israel
[3] Rambam Med Ctr, Dermatopathol Unit, IL-31096 Haifa, Israel
[4] Technion Israel Inst Technol, Bruce Rappaport Fac Med, IL-31096 Haifa, Israel
关键词
epidermolysis bullosa; immunopathology;
D O I
10.1097/00000372-199904000-00015
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Routine histologic study usually is insufficient to subclassify epidermolysis bullosa (EB); currently, electron microscopic evaluation has been the gold standard. A major advance recently has been made in elucidating the molecular basis of several major forms of EB. Concomitantly, immunoreagents have been developed to map antigens in the basement membrane zone. Some of these reagents facilitate the classification of EB into types and subtypes and can be used as an adjunct informative screening procedure to direct mutation identification efforts using DNA technologies. The current review provides an overview of these recent developments and a more detailed account of the immunohistopathologic diagnosis of EB.
引用
收藏
页码:185 / 192
页数:8
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