Natural killer cell-directed therapies: moving from unexpected results to successful strategies

被引：235

作者：

Terme, Magali ^{[1
]}

Ullrich, Evelyn ^{[1
]}

Delahaye, Nicolas F. ^{[1
]}

Chaput, Nathalie ^{[1
]}

Zitvogel, Laurence ^{[1
,2
]}

机构：

[1] Inst Gustave Roussy, INSERM, U805, Ctr Invest Clin BT 507, F-94805 Villejuif, France

[2] Univ Paris Sud, Fac Med, F-94276 Le Kremlin Bicetre, France

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 05期

关键词：

D O I：

10.1038/ni1580

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells influence innate and adaptive immune host defenses. Existing data indicate that manipulating the balance between inhibitory and activating NK receptor signals, the sensitivity of target cells to NK cell-mediated apoptosis, and NK cell cross-talk with dendritic cells might hold therapeutic promise. Efforts to modulate NK cell trafficking into inflamed tissues and/or lymph nodes, and to counteract NK cell suppressors, might also prove fruitful in the clinic. However, deeper investigation into the benefits of combination therapy, greater understanding of the functional distinctions between NK cell subsets, and design of new tools to monitor NK cell activity are needed to strengthen our ability to harness the power of NK cells for therapeutic aims.

引用

页码：486 / 494

页数：9

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