Synthesis and comparative evaluation of two antiviral agents:: β-L-Fd4C and β-D-Fd4C

被引：21

作者：

Chen, SH

Lin, S

King, I

Spinka, T

Dutschman, GE

Gullen, EA

Cheng, YC

Doyle, TW

机构：

[1] Vion Pharmaceut Inc, New Haven, CT 06511 USA

[2] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA

[3] Yale Univ, Sch Med, Ctr Comprehens Canc, New Haven, CT 06520 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(98)00599-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of beta-D-Fd(4)C was achieved in a stereoselective fashion fi om D-xylose. The antiviral activity and cytotoxicity of beta-D-Fd(4)C was compared with that of beta-L-Fd(4)C and 3TC (Lamivudine). Of the three agents compared, beta-L-Fd(4)C was found to be the most potent antiviral agent. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3245 / 3250

页数：6

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