Broader distribution of plasmid-mediated quinolone resistance in the United States

被引：78

作者：

Robicsek, A

Sahm, DF

Strahilevitz, J

Jacoby, GA

Hooper, DC

机构：

[1] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA

[2] Focus Technol, Herndon, VA USA

[3] Lahey Clin Fdn, Burlington, MA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 07期

关键词：

D O I：

10.1128/AAC.49.7.3001-3003.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The plasmid-encoded quinolone resistance gene qnrA confers low-level quinolone resistance, facilitating selection of higher-level resistance. Epidemiologic surveys for qnrA were extended to isolates of Enterobacter spp. and to quinolone-susceptible Enterobacteriaceae. Two (10%) of 20 ceftazidime-resistant quinolone-susceptible Klebsiella pneumoniae strains carried the gene, as did 12 (17%) of 71 ceftazidime-resistant Enterobacter strains from across the United States. One of these Enterobacter isolates was quinolone susceptible. Thus, qnrA is present in quinolone-resistant and quinolone-susceptible Enterobacter and Klebsiella strains in the United States.

引用

收藏

页码：3001 / 3003

页数：3

相关论文

共 11 条

[1] Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneti 2b [J].

Hata, M ;

Suzuki, M ;

Matsumoto, M ;

Takahashi, M ;

Sato, K ;

Ibe, S ;

Sakae, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (02) :801-803

[2] CHARACTERIZATION OF FLUORO QUINOLONE-RESISTANT MUTANTS OF ESCHERICHIA-COLI SELECTED IN-VITRO [J].

HEISIG, P ;

TSCHORNY, R .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (06) :1284-1291

[3]

JACOB AE, 1977, DNA INSERTION ELEMEN, P607

[4] Plasmid-mediated quinolone resistance in isolates obtained in German intensive care units [J].

Jonas, D ;

Biehler, Y ;

Hartung, D ;

Spitzmüller, B ;

Daschner, FD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (02) :773-775

[5] MULTIPLE PLASMID-CONTAINING ESCHERICHIA-COLI STRAIN - CONVENIENT SOURCE OF SIZE REFERENCE PLASMID MOLECULES [J].

MACRINA, FL ;

KOPECKO, DJ ;

JONES, KR ;

AYERS, DJ ;

MCCOWEN, SM .

PLASMID, 1978, 1 (03) :417-420

[6] Emergence of plasmid-mediated quinolone resistance in Escherichia coli in Europe [J].

Mammeri, H ;

Van de Loo, M ;

Poirel, L ;

Martinez-Martinez, L ;

Nordmann, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (01) :71-76

[7] Quinolone resistance from a transferable plasmid [J].

Martínez-Martínez, L ;

Pascual, A ;

Jacoby, GA .

LANCET, 1998, 351 (9105) :797-799

[8] Interaction of plasmid and host quinolone resistance [J].

Martínez-Martínez, L ;

Pascual, A ;

García, I ;

Tran, J ;

Jacoby, GA .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 (04) :1037-1039

[9] Mechanism of plasmid-mediated quinolone resistance [J].

Tran, JH ;

Jacoby, GA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5638-5642

[10] Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States [J].

Wang, MG ;

Sahm, DF ;

Jacoby, GA ;

Hooper, DC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (04) :1295-1299