Retinal remodeling during retinal degeneration

被引：359

作者：

Jones, BW ^{[1
]}

Marc, RE ^{[1
]}

机构：

[1] Moran Eye Ctr, Salt Lake City, UT 84132 USA

来源：

EXPERIMENTAL EYE RESEARCH | 2005年 / 81卷 / 02期

关键词：

plasticity; computational molecular phenotyping; retina; remodeling; amacrine cell; photoreceptor; ganglion cell; bipolar cell; horizontal cell; retinitis pigmentosa; RCS; rd1; rd2; or(J); pcd; nr(J); GHL; rho Delta CTA; TG9N; rdcl; P23H; S334ter; or(J)+P27Kip1(-/-); rho(-/-); elovl4(-/-); hrhoG; hrhoG(H); hrhoG+rd1; light damage;

D O I：

10.1016/j.exer.2005.03.006

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic glutamatergic drive of the sensory retina and, perhaps more importantly, removes coordinated Ca++-coupled signaling to the neural retina. As in other central nervous system degenerations, deafferentation activates remodeling. Neuronal remodeling is the common fate of all photoreceptor degenerations. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：123 / 137

页数：15

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