Retinal remodeling during retinal degeneration

被引：359

作者：

Jones, BW ^{[1
]}

Marc, RE ^{[1
]}

机构：

[1] Moran Eye Ctr, Salt Lake City, UT 84132 USA

来源：

EXPERIMENTAL EYE RESEARCH | 2005年 / 81卷 / 02期

关键词：

plasticity; computational molecular phenotyping; retina; remodeling; amacrine cell; photoreceptor; ganglion cell; bipolar cell; horizontal cell; retinitis pigmentosa; RCS; rd1; rd2; or(J); pcd; nr(J); GHL; rho Delta CTA; TG9N; rdcl; P23H; S334ter; or(J)+P27Kip1(-/-); rho(-/-); elovl4(-/-); hrhoG; hrhoG(H); hrhoG+rd1; light damage;

D O I：

10.1016/j.exer.2005.03.006

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Retinal degenerations, regardless of the initiating event or gene defect, often result in a loss of photoreceptors. This formal deafferentation of the neural retina eliminates the intrinsic glutamatergic drive of the sensory retina and, perhaps more importantly, removes coordinated Ca++-coupled signaling to the neural retina. As in other central nervous system degenerations, deafferentation activates remodeling. Neuronal remodeling is the common fate of all photoreceptor degenerations. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：123 / 137

页数：15

相关论文

共 101 条

[31]

Frederick JM, 2001, INVEST OPHTH VIS SCI, V42, P826

[32] Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors [J].

Freedman, MS ;

Lucas, RJ ;

Soni, B ;

von Schantz, M ;

Muñoz, M ;

David-Gray, Z ;

Foster, R .

SCIENCE, 1999, 284 (5413) :502-504

[33] Regulation of hippocampal synaptic plasticity by the tyrosine kinase receptor, REK7/EphA5, and its ligand, AL-1/Ephrin-A5 [J].

Gao, WQ ;

Shinsky, N ;

Armanini, MP ;

Moran, P ;

Zheng, JL ;

Mendoza-Ramirez, JL ;

Phillips, HS ;

Winslow, JW ;

Caras, IW .

MOLECULAR AND CELLULAR NEUROSCIENCE, 1998, 11 (5-6) :247-259

[34] RETINAL DAMAGE BY VISIBLE LIGHT [J].

GORN, RA ;

KUWABARA, T .

ARCHIVES OF OPHTHALMOLOGY, 1967, 77 (01) :115-&

[35] Genetic rescue of cell number in a mouse model of microphthalmia: interactions between Chx10 and G1-phase cell cycle regulators [J].

Green, ES ;

Stubbs, JL ;

Levine, EM .

DEVELOPMENT, 2003, 130 (03) :539-552

[36] Alterations in NMDA receptor expression during retinal degeneration in the RCS rat [J].

Gründer, T ;

Kohler, K ;

Guenther, E .

VISUAL NEUROSCIENCE, 2001, 18 (05) :781-787

[37] Regenerating motor neurons express Nna1, a novel ATP/GTP-binding protein related to zinc carboxypeptidases [J].

Harris, A ;

Morgan, JI ;

Pecot, M ;

Soumare, A ;

Osborne, A ;

Soares, HD .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2000, 16 (05) :578-596

[38] Dissociated retinal neurons form periodically active synaptic circuits [J].

Harris, RE ;

Coulombe, MG ;

Feller, MB .

JOURNAL OF NEUROPHYSIOLOGY, 2002, 88 (01) :188-195

[39] AUTOSOMAL DOMINANT SECTORAL RETINITIS-PIGMENTOSA - 2 FAMILIES WITH TRANSVERSION MUTATION IN CODON 23 OF RHODOPSIN [J].

HECKENLIVELY, JR ;

RODRIGUEZ, JA ;

DAIGER, SP .

ARCHIVES OF OPHTHALMOLOGY, 1991, 109 (01) :84-91

[40] Visual perception elicited by electrical stimulation of retina in blind humans [J].

Humayun, MS ;

deJuan, E ;

Dagnelie, G ;

Greenberg, RJ ;

Prost, RH ;

Phillips, DH .

ARCHIVES OF OPHTHALMOLOGY, 1996, 114 (01) :40-46

← 1 2 3 4 5 6 7 8 9 10 →