Synthesis of the tricyclic core of the marine natural product labiatin A

被引：12

作者：

Clark, JS

Baxter, CA

Castro, JL

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England

来源：

SYNTHESIS-STUTTGART | 2005年 / 19期

关键词：

carbenoid; ylide; rearrangement; stereoselective synthesis; natural product;

D O I：

10.1055/s-2005-918485

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic route to a model of the tricyclic core of labiatin A is described. Two catalytic metal carbenoid reactions, C-H insertion and oxonium ylide generation with subsequent [2,3]-sigmatropic rearrangement, have been used to assemble the tricyclic system in an efficient and stereoselective manner.

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收藏

页码：3398 / 3404

页数：7

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