Mice lacking histidine decarboxylase exhibit abnormal mast cells

被引：325

作者：

Ohtsu, H

Tanaka, S

Terui, T

Hori, Y

Makabe-Kobayashi, Y

Pejler, G

Tchougounova, E

Hellman, L

Gertsenstein, M

Hirasawa, N

Sakurai, E

Buzás, E

Kovács, P

Csaba, G

Kittel, A

Okada, M

Hara, M

Mar, L

Numayama-Tsuruta, K

Ishigaki-Suzuki, S

Ohuchi, K

Ichikawa, A

Falus, A

Watanabe, T

Nagy, A

机构：

[1] Tohoku Univ, Sch Med, Dept Cellular Pharmacol, Aoba Ku, Sendai, Miyagi 9808575, Japan

[2] Kyoto Univ, Fac Pharmaceut Sci, Dept Physiol Chem, Sakyo Ku, Kyoto 6068501, Japan

[3] Tohoku Univ, Sch Med, Dept Dermatol, Aoba Ku, Sendai, Miyagi 9808575, Japan

[4] Swedish Univ Agr Sci, Dept Vet Med Chem, S-75123 Uppsala, Sweden

[5] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[6] Tohoku Univ, Fac Pharmaceut Sci, Dept Pathophysiol Biochem, Sendai, Miyagi 9808578, Japan

[7] Semmelweis Univ, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

[8] Hungarian Acad Sci, Inst Expt Med, Budapest, Hungary

[9] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada

来源：

FEBS LETTERS | 2001年 / 502卷 / 1-2期

关键词：

mast cell; rodent; knockout; histamine;

D O I：

10.1016/S0014-5793(01)02663-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC-deficient mice using a gene targeting method. The mice showed a histamine deficiency and lacked histamine-synthesizing activity from histidine. These HDC-deficient mice are viable and fertile but exhibit a decrease in the numbers of mast cells while the remaining mast cells show an altered morphology and reduced granular content. The amounts of mast cell granular proteases were tremendously reduced. The HDC-deficient mice provide a unique and promising model for studying the role of histamine in a broad range of normal and disease processes. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：53 / 56

页数：4

共 18 条

[1] Mast cells and their mediators in cutaneous wound healing active participants or innocent bystanders? [J].