Microtubule motors: LSD2 trips the toggle

被引：7

作者：

Cohen, RS ^{[1
]}

机构：

[1] Univ Kansas, Dept Mol Biosci, Lawrence, KS 66045 USA

来源：

CURRENT BIOLOGY | 2005年 / 15卷 / 17期

关键词：

D O I：

10.1016/j.cub.2005.08.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Perilipin homologue LSD2 has been identified as a regulator of microtubule motor activity in Drosophila embryos. LSD2 is required for the net directional transport of lipid droplets and the new data support a model in which the protein imparts bias onto a molecular toggle that otherwise randomly engages minus and plus end motors in a paired set.

引用

收藏

页码：R651 / R653

页数：3

相关论文

共 14 条

[1] Halo: A guiding light for transport [J].

Cohen, RS .

CURRENT BIOLOGY, 2003, 13 (22) :R869-R870

[2] Control of fat storage by a Drosophila PAT domain protein [J].

Grönke, S ;

Beller, M ;

Fellert, S ;

Ramakrishnan, H ;

Jäckle, H ;

Kühnlein, RP .

CURRENT BIOLOGY, 2003, 13 (07) :603-606

[3] Coordination of opposite-polarity microtubule motors [J].

Gross, SP ;

Welte, MA ;

Block, SM ;

Wieschaus, EF .

JOURNAL OF CELL BIOLOGY, 2002, 156 (04) :715-724

[4] Dynein-mediated cargo transport in vivo: A switch controls travel distance [J].

Gross, SP ;

Welte, MA ;

Block, SM ;

Wieschaus, EF .

JOURNAL OF CELL BIOLOGY, 2000, 148 (05) :945-955

[5] A determinant for directionality of organelle transport in Drosophila embryos [J].

Gross, SP ;

Guo, Y ;

Martinez, JE ;

Welte, MA .

CURRENT BIOLOGY, 2003, 13 (19) :1660-1668

[6] Organelle-specific control of intracellular transport: Distinctly targeted isoforms of the regulator Klar [J].

Guo, Y ;

Jangi, S ;

Welte, MA .

MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (03) :1406-1416

[7] Molecular motors: Strategies to get along [J].

Mallik, R ;

Gross, SP .

CURRENT BIOLOGY, 2004, 14 (22) :R971-R982

[8] Absence of perilipin results in leanness and reverses obesity in Lepr db db mice [J].

Martinez-Botas, J ;

Anderson, JB ;

Tessier, D ;

Lapillonne, A ;

Chang, BHJ ;

Quast, MJ ;

Gorenstein, D ;

Chen, KH ;

Chan, L .

NATURE GENETICS, 2000, 26 (04) :474-479

[9] Functional conservation for lipid storage droplet association among perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium [J].

Miura, S ;

Gan, JW ;

Brzostowski, J ;

Parisi, MJ ;

Schultz, CJ ;

Londos, C ;

Oliver, B ;

Kimmel, AR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (35) :32253-32257

[10] Hydrophobic sequences target and anchor perilipin A to lipid droplets [J].

Subramanian, V ;

Garcia, A ;

Sekowski, A ;

Brasaemle, DL .

JOURNAL OF LIPID RESEARCH, 2004, 45 (11) :1983-1991