A divergent approach to the myriaporones and tedanolide: Enantioselective preparation of the common intermediate

被引：51

作者：

Taylor, RE ^{[1
]}

Ciavarri, JP ^{[1
]}

Hearn, BR ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 51期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(98)02110-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The tedanolide and myriaporone classes of natural products represent interesting targets for synthesis because of their structural similarity and biological activity. The asymmetric preparation of a potential common intermediate in the total synthesis of each of these targets is presented. The key step, a Zr-mediated allylation, allows for the efficient preparation of the hydroxypropionate structural unit. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9361 / 9364

页数：4

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