An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway

被引：881

作者：

Schiemann, B ^{[1
]}

Gommerman, JL ^{[1
]}

Vora, K ^{[1
]}

Cachero, TG ^{[1
]}

Shulga-Morskaya, S ^{[1
]}

Dobles, M ^{[1
]}

Frew, E ^{[1
]}

Scott, ML ^{[1
]}

机构：

[1] Biogen Inc, Cambridge, MA 02142 USA

来源：

SCIENCE | 2001年 / 293卷 / 5537期

关键词：

D O I：

10.1126/science.1061964

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The B cell activating factor BAFF (BtyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA.

引用

页码：2111 / 2114

页数：4

共 34 条

[1] BAFF mediates survival of peripheral immature B lymphocytes
Batten, M
Groom, J
Cachero, TG
Qian, F
Schneider, P
Tschopp, J
Browning, JL
Mackay, F
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (10) : 1453 - 1465
[2] Cheema GS, 2001, ARTHRITIS RHEUM-US, V44, P1313, DOI 10.1002/1529-0131(200106)44:6<1313::AID-ART223>3.0.CO
[3] 2-S
[4] B-1 cell development:: Evidence for an uncommitted immunoglobulin (Ig)M+ B cell precursor in B-1 cell differentiation
Clarke, SH
Arnold, LW
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (08) : 1325 - 1334
[5] Chemokines - Chemokines and cell migration in secondary lymphoid organs
Cyster, JG
[J]. SCIENCE, 1999, 286 (5447) : 2098 - 2102
[6] BCMAP - AN INTEGRAL MEMBRANE-PROTEIN IN THE GOLGI-APPARATUS OF HUMAN MATURE B-LYMPHOCYTES
GRAS, MP
LAABI, Y
LINARESCRUZ, G
BLONDEL, MO
RIGAUT, JP
BROUET, JC
LECA, G
HAGUENAUERTSAPIS, R
TSAPIS, A
[J]. INTERNATIONAL IMMUNOLOGY, 1995, 7 (07) : 1093 - 1106
[7] TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease
Gross, JA
Johnston, J
Mudri, S
Enselman, R
Dillon, SR
Madden, K
Xu, WF
Parrish-Novak, J
Foster, D
Lofton-Day, C
Moore, M
Littau, A
Grossman, A
Haugen, H
Foley, K
Blumberg, H
Harrison, K
Kindsvogel, W
Clegg, CH
[J]. NATURE, 2000, 404 (6781) : 995 - 999
[8] APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth
Hahne, M
Kataoka, T
Schröter, M
Hofmann, K
Irmler, M
Bodmer, JL
Schneider, P
Bornard, T
Holler, N
French, LE
Sordat, B
Rimoldi, D
Tschopp, J
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (06) : 1185 - 1190
[9] B cell development pathways
Hardy, RR
Hayakawa, K
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 : 595 - 621
[10] DISTINCTIVE DEVELOPMENTAL ORIGINS AND SPECIFICITIES OF MURINE CD5(+)B CELLS
HARDY, RR
CARMACK, CE
LI, YS
HAYAKAWA, K
[J]. IMMUNOLOGICAL REVIEWS, 1994, 137 : 91 - 118

← 1 2 3 4 →