An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway

被引：881

作者：

Schiemann, B ^{[1
]}

Gommerman, JL ^{[1
]}

Vora, K ^{[1
]}

Cachero, TG ^{[1
]}

Shulga-Morskaya, S ^{[1
]}

Dobles, M ^{[1
]}

Frew, E ^{[1
]}

Scott, ML ^{[1
]}

机构：

[1] Biogen Inc, Cambridge, MA 02142 USA

来源：

SCIENCE | 2001年 / 293卷 / 5537期

关键词：

D O I：

10.1126/science.1061964

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The B cell activating factor BAFF (BtyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Here we report an absolute requirement for BAFF in normal B cell development. Examination of secondary lymphoid organs from BAFF-deficient mice revealed an almost complete loss of follicular and marginal zone B lymphocytes. In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA.

引用

页码：2111 / 2114

页数：4

共 34 条

[21] PHENOTYPIC AND GENETIC-CHARACTERIZATION OF A UNIQUE LYMPHOCYTE-B DEFICIENCY IN STRAIN A/WYSNJ MICE
MILLER, DJ
HAYES, CE
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (05) : 1123 - 1130
[22] BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator
Moore, PA
Belvedere, O
Orr, A
Pieri, K
LaFleur, DW
Feng, P
Soppet, D
Charters, M
Gentz, R
Parmelee, D
Li, YL
Galperina, O
Giri, J
Roschke, V
Nardelli, B
Carrell, J
Sosnovtseva, S
Greenfield, W
Ruben, SM
Olsen, HS
Fikes, J
Hilbert, DM
[J]. SCIENCE, 1999, 285 (5425) : 260 - 263
[23] Identification and characterization of a novel cytokine, THANK, a (T)under-barNF (H)under-baromologue that activates (A)under-barpoptosis, nuclear factor-κB, and c-Jun NH2-terminal (K)under-barinase
Mukhopadhyay, A
Ni, J
Zhai, YF
Yu, GL
Aggarwal, BB
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (23) : 15978 - 15981
[24] Nemazee D, 2000, Adv Immunol, V74, P89
[25] A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth
Rennert, P
Schneider, P
Cachero, TG
Thompson, J
Trabach, L
Hertig, S
Holler, N
Qian, F
Mullen, C
Strauch, K
Browning, JL
Ambrose, C
Tschopp, J
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (11) : 1677 - 1683
[26] BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
Schneider, P
MacKay, F
Steiner, V
Hofmann, K
Bodmer, JL
Holler, N
Ambrose, C
Lawton, P
Bixler, S
Acha-Orbea, H
Valmori, D
Romero, P
Werner-Favre, C
Zubler, RH
Browning, JL
Tschopp, J
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (11) : 1747 - 1756
[27] TALL-1 is a novel member of the TNF family that is down-regulated by mitogens
Shu, HB
Hu, WH
Johnson, H
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1999, 65 (05) : 680 - 683
[28] BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF
Thompson, JS
Bixler, SA
Qian, F
Vora, K
Scott, ML
Cachero, TG
Hession, C
Schneider, P
Sizing, ID
Mullen, C
Strauch, K
Zafari, M
Benjamin, CD
Tschopp, J
Browning, JL
Ambrose, C
[J]. SCIENCE, 2001, 293 (5537) : 2108 - 2111
[29] Regulation of the T-independent humoral response by TACI
von Bülow, GU
van Deursen, JM
Bram, RJ
[J]. IMMUNITY, 2001, 14 (05) : 573 - 582
[30] NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily
vonBulow, GU
Bram, RJ
[J]. SCIENCE, 1997, 278 (5335) : 138 - 141

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