Catalysis of hydrolysis of a phosphate diester by mono- and dinuclear macrocyclic zinc(II) complexes

被引：58

作者：

Jurek, P ^{[1
]}

Martell, AE ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

来源：

INORGANICA CHIMICA ACTA | 1999年 / 287卷 / 01期

关键词：

stability constants; hydrolysis; phosphate diester complexes; zinc complexes; macrocyclic ligand complexes;

D O I：

10.1016/S0020-1693(98)00404-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The macrocyclic ligand 3,6,9,17,20,23-hexaazatricyclo[23.3.1.1(11.15)]1, 11, 13, 15, 25, 27-hexaene (BMXD) forms a variety of mononuclear and dinuclear zinc complexes in 75% ethanol. Monohydroxo complexes of both the mononuclear and dinuclear species form in solution. The ability of these monohydroxo complexes to catalyze the hydrolysis of bis(4-nitrophenyl) phosphate (BNP) was studied. The L-Zn-OH complex forms at a higher pH than does the dinuclear analog, and is more effective at hydrolyzing BNP than L-Zn-2-OH. Mechanisms for the hydrolysis of BNP are proposed, exploring the coordination mode of the substrate and the nucleophilicity of the attacking hydroxide. (C) 1999 Elsevier Science S.A. All rights reserved.

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页码：47 / 51

页数：5

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