Chemo-enzymatic approach to statin side-chain building blocks

被引：40

作者：

Öhrlein, R ^{[1
]}

Baisch, G ^{[1
]}

机构：

[1] CIBA SC Grp Res, CH-4002 Basel, Switzerland

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2003年 / 345卷 / 6-7期

关键词：

atorvastatin; aza-Wittig-reaction; enzymatic desymmetrisation; statin side-chain;

D O I：

10.1002/adsc.200303028

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A versatile statin side-chain building block is obtained by an enzymatic desymmetrisation of the symmetrical glutaric acid diethyl ester. The monoacid is produced in almost quantitative yield in the desired high optical purity. The monoacid is easily converted to the corresponding acid chloride, which is a key compound to be elaborated to some statin side-chain derivatives. The optically active C-5 chain is subsequently elongated by two carbon atoms and syn-reduced to the final diol fragment.

引用

页码：713 / 715

页数：3

共 14 条

[1]

BECK G, 1995, SYNTHESIS-STUTTGART, P1014

[2] POLYHYDROXYLATED CHIRAL BUILDING BLOCK BY ENZYMATIC DESYMMETRIZATION OF MESO 1,3 SYN DIOLS [J].