POLYHYDROXYLATED CHIRAL BUILDING BLOCK BY ENZYMATIC DESYMMETRIZATION OF MESO 1,3 SYN DIOLS

被引：31

作者：

BONINI, C ^{[1
]}

RACIOPPI, R ^{[1
]}

RIGHI, G ^{[1
]}

VIGGIANI, L ^{[1
]}

机构：

[1] UNIV LA SAPIENZA,CNR,DIPARTIMENTO CHIM,CTR CHIM SOSTANZE ORGAN NAT,I-00185 ROME,ITALY

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 04期

关键词：

D O I：

10.1021/jo00056a002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new seven-carbon polyhydroxylated chiral synthon is obtained, as single enantiomer, in nearly quantitative yield by enzymatic desymmetrization of the appropriate meso compound. Pseudomonas fluorescens shows an high degree of enantiotopic discrimination in a particularly complex molecule possessing a 1,3 syn diol structure; likewise, this chiral synthon has been easily transformed into a known compactin analogue.

引用

页码：802 / 803

页数：2

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