Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis

被引：22

作者：

Salvi, R ^{[1
]}

Péclat, V ^{[1
]}

So, A ^{[1
]}

Busso, N ^{[1
]}

机构：

[1] CHU Vaudois, Lab Rhumatol, CH-1011 Lausanne, Switzerland

来源：

ARTHRITIS RESEARCH | 2000年 / 2卷 / 06期

关键词：

arthritis; coagulation; fibrinolysis; mice; RNase protection;

D O I：

10.1186/ar132

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have analyzed the pattern of procoagulant and fibrinolytic gene expression in affected joints during the course of arthritis in two murine models. In both models, we found an increased expression of tissue factor, tissue factor pathway inhibitor, urokinase plasminogen activator, and plasminogen activator inhibitor 1, as well as thrombin receptor. The observed pattern of gene expression tended to favor procoagulant activity, and this pattern was confirmed by functional assays. These alterations would account for persistence of fibrin within the inflamed joint, as is seen in rheumatoid arthritis.

引用

页码：504 / 512

页数：9

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