Tripropeptins, novel antimicrobial agents produced by Lysobacter sp -: II.: Structure elucidation

被引：52

作者：

Hashizume, H

Hirosawa, S

Sawa, R

Muraoka, Y

Ikeda, D

Naganawa, H

Igarashi, M

机构：

[1] Microbial Chem Res Ctr, Shinagawa Ku, Tokyo 1410021, Japan

[2] Hiyoshi Med Chem Res Inst, Microbial Chem Res Ctr, Nakahara Ku, Kanagawa 2110035, Japan

[3] Numazu Biomed Res Inst, Microbial Chem Res Ctr, Shizuoka 4100301, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2004年 / 57卷 / 01期

关键词：

D O I：

10.7164/antibiotics.57.52

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Planar structures of tripropeptins (TPPs) were elucidated by spectroscopic studies including various NMR measurements. Stereochemistry of constituent amino acids of tripropeptin C (TPPC) (3) was identified by marfey's method except hydroxyproline which was determined by studies of NMR and CD spectra. The absolute structure of 3 was determined by analyses of the fragments obtained by Birch reduction and LiBH4 reduction of 3. The configuration of the fatty acid, isolated from acid hydrolysate of 3, was determined to be (3R)-hydroxy-13-methyltetradecanoic acid from MS, NMR spectra and negative sign of the optical rotation.

引用

页码：52 / 58

页数：7

共 7 条

[1] REDUCTIVE CLEAVAGE OF ACYLPROLINE PEPTIDE BONDS [J].