Effects of single and repeated phencyclidine administration on the expression of metabotropic glutamate receptor subtype mRNAs in rat brain

被引:23
作者
Abe, S
Suzuki, T
Ito, T
Yamaguchi, M
Baba, A
Hori, T
Kurita, H
Shiraishi, H
Okado, N
机构
[1] Univ Tsukuba, Inst Clin Med, Dept Psychiat, Tsukuba, Ibaraki 3058575, Japan
[2] Univ Tsukuba, Inst Basic Med Sci, Dept Anat, Neurobiol Lab, Tsukuba, Ibaraki 3058575, Japan
[3] Okayama Univ, Fac Educ, Okayama 7008530, Japan
关键词
metabotropic glutamate receptor; phencyclidine; NMDA antagonist; glutamate; schizophrenia; in situ hybridization;
D O I
10.1016/S0893-133X(00)00250-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent animal studies regarding phencyclidine (PCP), which induces psychotic symptoms in humans, have suggested that g-roup II metabotropic glutamate receptors (mGluRs) represent a novel target for the treatment of PCP psychosis. In the present study, we used in situ hybridization to investigate the gene expressions of the mGluR 1-5 subtypes following single and repeated administration of PCP in rats. A single administration Of PCP (7.5mg/kg, i.p.,) resulted in a significant decrease in the mGluR5 inRNA expression of group I inGluR in the subcortical regions (thalamus (-15%), central gray (-23%), inferior colliculus (-23%), and nucleus accumbens (-10%)) and hippocampal formation (CA1 (-14%), CA2 (-15%), CA3 (-18%), and dentate gyrus (-18%)). After repeated PCP administration for 14 days,, the mGluR2 inRNA expression of group II inGluR in the anterior cingulate cortex (-23%) and the mGluR4 mRNA expression of group III mGluR in the cortical regions (parietal (-11%), temporal (-13%) and entorhinal cortices (-18%)), the caudate putamen (-12%), thalamus (-17%), and subiculum (-25%) were significantly decreased. These results indicate that PCP affects not only group II mGluR but also group I and III of mGluR, and it is of particular interest that mGluR2 subtype is involved in a development of behavioral abnormality following repeated PCP administration. Single and repeated administrations of PCP independently regulate the expression of mGluR subtypes of mRNA in the brain. [Neuropsychopharmacology 25:173-184,2001] (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
引用
收藏
页码:173 / 184
页数:12
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