How shall we use the proteomics toolbox for biomarker discovery?

被引：122

作者：

Lescuyer, Pierre

Hochstrasser, Denis

Rabilloud, Thierry ^{[1
]}

机构：

[1] Univ Geneva, Fac Sci, Fac Med, Dept Stuct Biol & Bioinformat, Geneva, Switzerland

[2] Univ Geneva, Fac Sci, Fac Med, Pharm Sect, Geneva, Switzerland

[3] Univ Geneva, Dept Genet, Lab Med Serv, Lab Med, CH-1211 Geneva, Switzerland

[4] BBSI, CEA, DSV, iRTSV, F-38054 Grenoble 9, France

[5] CNRS, UMR 5092, F-38054 Grenoble 9, France

来源：

JOURNAL OF PROTEOME RESEARCH | 2007年 / 6卷 / 09期

关键词：

proteomics; biomarkers; plasma; biological fluids; cerebrospinal fluid;

D O I：

10.1021/pr0702060

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Biomarker discovery for clinical purposes is one of the major areas in which proteomics is used. However, despite considerable effort, the successes have been relatively scarce. In this perspective paper, we try to highlight and analyze the main causes for this limited success, and to suggest alternate strategies, which will avoid them, without eluding the foreseeable weak points of these strategies. Two major strategies are analyzed, namely, the switch from body fluids to cell and tissues for the initial biomarker discovery step or, if body fluids must be analyzed, the implementation of highly selective protein selection strategies.

引用

收藏

页码：3371 / 3376

页数：6

相关论文

共 38 条

[1] Proteomic-based identification of haptoglobin-1 precursor as a novel circulating biomarker of ovarian cancer [J].

Ahmed, N ;

Barker, G ;

Oliva, KT ;

Hoffmann, P ;

Riley, C ;

Reeve, S ;

Smith, AL ;

Kemp, BE ;

Quinn, MA ;

Rice, GE .

BRITISH JOURNAL OF CANCER, 2004, 91 (01) :129-140

[2]

Aksamit AJ, 2003, ARCH NEUROL-CHICAGO, V60, P803, DOI 10.1001/archneur.60.6.803

[3] PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke [J].

Allard, L ;

Burkhard, PR ;

Lescuyer, P ;

Burgess, JA ;

Walter, N ;

Hochstrasser, DF ;

Sanchez, JC .

CLINICAL CHEMISTRY, 2005, 51 (11) :2043-2051

[4] Characterization of the human visceral adipose tissue secretome [J].

Alvarez-Llamas, Gloria ;

Szalowska, Ewa ;

de Vries, Marcel P. ;

Weening, Desiree ;

Landman, Karloes ;

Hoek, Annemieke ;

Wolffenbuttel, Bruce H. R. ;

Roelofsen, Han ;

Vonk, Roel J. .

MOLECULAR & CELLULAR PROTEOMICS, 2007, 6 (04) :589-600

[5] Serum transaminase elevations as indicators of hepatic injury following the administration of drugs [J].

Amacher, DE .

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 1998, 27 (02) :119-130

[6] Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy [J].

Amacher, DE ;

Adler, R ;

Herath, A ;

Townsend, RR .

CLINICAL CHEMISTRY, 2005, 51 (10) :1796-1803

[7] Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins [J].

Anderson, L ;

Hunter, CL .

MOLECULAR & CELLULAR PROTEOMICS, 2006, 5 (04) :573-588

[8] Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes [J].

Antman, EM ;

Tanasijevic, MJ ;

Thompson, B ;

Schactman, M ;

McCabe, CH ;

Cannon, CP ;

Fischer, GA ;

Fung, AY ;

Thompson, C ;

Wybenga, D ;

Braunwald, E .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (18) :1342-1349

[9] Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework [J].

Atkinson, AJ ;

Colburn, WA ;

DeGruttola, VG ;

DeMets, DL ;

Downing, GJ ;

Hoth, DF ;

Oates, JA ;

Peck, CC ;

Schooley, RT ;

Spilker, BA ;

Woodcock, J ;

Zeger, SL .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) :89-95

[10]

Bachmeier BE, 2001, ANTICANCER RES, V21, P3821

← 1 2 3 4 →