How shall we use the proteomics toolbox for biomarker discovery?

被引:122
作者
Lescuyer, Pierre
Hochstrasser, Denis
Rabilloud, Thierry [1 ]
机构
[1] Univ Geneva, Fac Sci, Fac Med, Dept Stuct Biol & Bioinformat, Geneva, Switzerland
[2] Univ Geneva, Fac Sci, Fac Med, Pharm Sect, Geneva, Switzerland
[3] Univ Geneva, Dept Genet, Lab Med Serv, Lab Med, CH-1211 Geneva, Switzerland
[4] BBSI, CEA, DSV, iRTSV, F-38054 Grenoble 9, France
[5] CNRS, UMR 5092, F-38054 Grenoble 9, France
关键词
proteomics; biomarkers; plasma; biological fluids; cerebrospinal fluid;
D O I
10.1021/pr0702060
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Biomarker discovery for clinical purposes is one of the major areas in which proteomics is used. However, despite considerable effort, the successes have been relatively scarce. In this perspective paper, we try to highlight and analyze the main causes for this limited success, and to suggest alternate strategies, which will avoid them, without eluding the foreseeable weak points of these strategies. Two major strategies are analyzed, namely, the switch from body fluids to cell and tissues for the initial biomarker discovery step or, if body fluids must be analyzed, the implementation of highly selective protein selection strategies.
引用
收藏
页码:3371 / 3376
页数:6
相关论文
共 38 条
[21]   Stage-dependent increase of orosomucoid and zinc-alpha2-glycoprotein in urinary bladder cancer [J].
Irmak, S ;
Tilki, D ;
Heukeshoven, J ;
Oliveira-Ferrer, L ;
Friedrich, M ;
Huland, H ;
Ergün, S .
PROTEOMICS, 2005, 5 (16) :4296-4304
[22]   Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness [J].
Jessani, N ;
Liu, YS ;
Humphrey, M ;
Cravatt, BF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (16) :10335-10340
[23]   Proteomic analysis of cerebrospinal fluid discriminates malignant and nonmalignant disease of the central nervous system and identifies specific protein markers [J].
Khwaja, Fatima W. ;
Nolen, John David Larkin ;
Mendrinos, Savaas E. ;
Lewis, Melinda M. ;
Olson, Jeffrey J. ;
Pohl, Jan ;
Van Meir, Erwin G. ;
Ritchie, James C. ;
Brat, Daniel J. .
PROTEOMICS, 2006, 6 (23) :6277-6287
[24]   Proteomic analysis of astrocytic secretion in the mouse -: Comparison with the cerebrospinal fluid proteome [J].
Lafon-Cazal, M ;
Adjali, O ;
Galélotti, N ;
Poncet, J ;
Jouin, P ;
Homburger, V ;
Bockaert, J ;
Marin, P .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (27) :24438-24448
[25]   Identification of serum amyloid a as a biomarker to distinguish prostate cancer patients with bone lesions [J].
Le, L ;
Chi, K ;
Tyldesley, S ;
Flibotte, S ;
Diamond, DL ;
Kuzyk, MA ;
Sadar, MD .
CLINICAL CHEMISTRY, 2005, 51 (04) :695-707
[26]   Identification of post-mortem cerebrospinal fluid proteins as potential biomarkers of ischemia and neurodegeneration [J].
Lescuyer, P ;
Allard, L ;
Zimmermann-Ivol, CG ;
Burgess, JA ;
Hughes-Frutiger, S ;
Burkhard, PR ;
Sanchez, JC ;
Hochstrasser, DF .
PROTEOMICS, 2004, 4 (08) :2234-2241
[27]   Activity-based protein profiling: The serine hydrolases [J].
Liu, YS ;
Patricelli, MP ;
Cravatt, BF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :14694-14699
[28]   CARDIAC TROPONIN-T IN THE DIAGNOSIS OF MYOCARDIAL INJURY [J].
MAIR, J ;
DIENSTL, F ;
PUSCHENDORF, B .
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 1992, 29 (01) :31-57
[29]   Clinical proteomics: A need to define the field and to begin to set adequate standards [J].
Mischak, Harald ;
Apweiler, Rolf ;
Banks, Rosamonde E. ;
Conaway, Mark ;
Coon, Joshua ;
Dominiczak, Anna ;
Ehrich, Jochen H. H. ;
Fliser, Danilo ;
Girolami, Mark ;
Hermjakob, Henning ;
Hochstrasser, Denis ;
Jankowski, Joachim ;
Julian, Bruce A. ;
Kolch, Walter ;
Massy, Ziad A. ;
Neusuess, Christian ;
Novak, Jan ;
Peter, Karlheinz ;
Rossing, Kasper ;
Schanstra, Joost ;
Semmes, O. John ;
Theodorescu, Dan ;
Thongboonkerd, Visith ;
Weissinger, Eva M. ;
Van Eyk, Jennifer E. ;
Yamamoto, Tadashi .
PROTEOMICS CLINICAL APPLICATIONS, 2007, 1 (02) :148-156
[30]   Effects of preanalytical variables on peptide and protein measurements in human serum and plasma: implications for clinical proteomics [J].
Rai, Alex J. ;
Vitzthum, Frank .
EXPERT REVIEW OF PROTEOMICS, 2006, 3 (04) :409-426