High transfection efficiency of poly(4-vinylimidazole) as a new gene carrier

被引：40

作者：

Ihm, JE

Han, KO

Han, IK

Ahn, KD

Han, DK

Cho, CS ^{[1
]}

机构：

[1] Seoul Natl Univ, Sch Agr Biotechnol, Suwon 441744, South Korea

[2] Sungkyunkwan Univ, Dept Internal Med, Sch Med, Seoul 100380, South Korea

[3] Korea Inst Sci & Technol, Biomed Res Ctr, Seoul 130650, South Korea

来源：

BIOCONJUGATE CHEMISTRY | 2003年 / 14卷 / 04期

关键词：

D O I：

10.1021/bc025611q

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Poly(4-vinylimidazole) (P4V) was obtained by free radical polymerization of 4-vinylimidazole (4V) prepared by decarboxylation of urocanic acid. P4V formed a complex with DNA that exhibited higher transfection effiency on Hela cells than polyethylenimine (PEI), through the proton sponge mechanism of the imidazole groups in the side chain of the P4V, and low cell toxicity.

引用

页码：707 / 708

页数：2

共 13 条

[11] ADENOVIRUS-MEDIATED TRANSFER OF A RECOMBINANT ALPHA-L-ANTITRYPSIN GENE TO THE LUNG EPITHELIUM INVIVO [J].