Synthesis of betulinic acid derivatives with activity against human melanoma

被引：142

作者：

Kim, DSHL ^{[1
]}

Pezzuto, JM ^{[1
]}

Pisha, E ^{[1
]}

机构：

[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Dept Med Chem & Pharmacognosy MC 833, Chicago, IL 60612 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(98)00295-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Betulinic acid has been modified at C-3, C-20, and C-28 positions and the toxicity of the derivatives has been evaluated against cultured human melanoma (MEL-2) and human epidermoid carcinoma of the mouth (KB) cell lines. This preliminary investigation demonstrates that simple modifications of the parent structure of betulinic acid can produce potentially important derivatives, which may be developed as antitumor drugs. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：1707 / 1712

页数：6

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